2011 Fiscal Year Final Research Report
PHYSIOLOGICAL FUNCTIONS OF WATER-SOLUBLE FLAVONOID DERIVATIVES IN OSTEOPOROTIC RODENTS
| Project/Area Number |
21580155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
UEHARA Mariko 東京農業大学, 応用生物科学部, 教授 (20211071)
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| Project Period (FY) |
2009 – 2011
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| Keywords | イソフラボン / ヘスペリジン / 水溶性フラボノイド / サイクロデキストリン / 原発性骨粗鬆症 / 続発性骨粗鬆症 / 2型糖尿病 |
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| Research Abstract |
Since native flavonoids are typical hydrophobic compounds, the compounds have not been frequently used as multipurpose food additives. Enzymatic modified-soy bean isoflavone and hesperidin, and cyclodextrin-clathrated(CD) hesperetin, a citrus bioflavonoid, have higher water-solubility than native corresponding flavonoids. Those water-soluble flavonoid derivates showed high bioavailability, and especially, CD-hesperetin improved secondary osteoporosis in both weanling and old type 2 diabetic rodents.
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