2011 Fiscal Year Final Research Report
The study of the immune responses of the large intestine regulated by the commensal bacteria and the immunomodulation by foods
| Project/Area Number |
21580158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
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| Co-Investigator(Kenkyū-buntansha) |
KAMINOGAWA Shuici 日本大学, 生物資源科学部, 教授 (50011945)
TAKAHASHI Kyoko 日本大学, 生物資源科学部, 講師 (70366574)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腸内細菌 / 大腸 / 免疫 / IgA / 共生 |
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| Research Abstract |
There are huge numbers of commensal bacteria in the large intestine. In this study, we have found the immunoregulatory mechanism of anti-infectious responses(e. g. IgA production and germinal center formation) and the hyporesponsiveness of mucosal immunocytes to commensal bacteria in the large intestine.
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[Journal Article] Bacteroidesを定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
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Journal Title
無菌生物
Volume: 40
Pages: 64-68
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[Presentation] Lactobacillus mono-associated mice might be down-regulated the serum antibody levels induced by dietary antigen compared with Bacteroides mono-associated mice2012
Author(s)
Hamamoto Y, Hosono A, Tsuda M, Kamoi D, Hachimura S, Momose Y, Itoh K, Hirayama K, Takahashi K, Kaminogawa S
Organizer
The joint Meeting of the 17th International Symposium on Gnotobiology(ISG) and the 34th Congress of the Society for Microbial Ecology and Disease(SOMED)
Place of Presentation
Yokohama, Japan
Year and Date
20121120-23
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[Presentation] Bacteroidesを定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
Organizer
第43回日本無菌生物ノートバイオロジー学会総会
Place of Presentation
東京
Year and Date
20100121-22
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[Presentation] CD3-IL-2R^+Peyer's patch cells respond to microbial stimuli, migrate to the lamina propria, secrete IL-5, and induce IgA production.2009
Author(s)
Umeda Y, Oawa S, Kaoka M, Takahashi Y, Itoh K, Yamada K, Kouro T, Tsuji N M, Hosono A, Totsuka M, Takatsu K, Kaminogawa S, Sato R, Hachimura S
Organizer
The 14th International Congress of Mucosal Immunology(ICMI 2009)
Place of Presentation
Boston, Massachusetts, USA
Year and Date
20090705-09
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