2011 Fiscal Year Final Research Report
Physiological function of RegIV, an antimicrobial lectin secreted from intestinal epithelia
| Project/Area Number |
21580159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 食品安全性 / 感染防御 |
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| Research Abstract |
Function of RegIV, an antimicrobial lectin secreted from intestinal epithelia, was analyzed using recombinant human RegIV protein. Analysis of ligand binding property using sugar-coupled beads revealed that recombinant RegIV binds peptidoglycan form gram-positive bacteria. It was also shown that RegIV elicits bactericidal activity on E. coli through membrane permeabilization.
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