2011 Fiscal Year Final Research Report
Analysis on mechanism of development of sensitization which decides symptom onset of allergic disease
| Project/Area Number |
21580167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
ISHIKAWA Yuko 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (40353940)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAKI Kohji 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品機能研究領域, 上席研究員栄養機能ユニット長 (70174597)
GOTO Masao 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品機能研究領域, 主任研究員 (30302590)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アレルギー / 経口免疫寛容 / 抗原感作 / IgE / T細胞 / 皮膚アナフィラキシー反応 |
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| Research Abstract |
To approve the antigen sensitization or to become an allergic condition, it might be required to have the period when the antigen did not exist in the body. It is suggested that the hypersensitivity responses are caused by intermittent exposure of antigen when compared with continuous exposure. One of the reasons is that the IL-12 cytokine production from the antigen-presenting cell decreases at antigen withdrawal period. This fact has the possibility to improve the preventing or therapeutic efficacy of allergic diseases.
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