2011 Fiscal Year Final Research Report
Elucidation of functionality of equol-producing bacteria
| Project/Area Number |
21580168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
TAMURA Motoi 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (70353943)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hiroyuki 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品安全研究領域, 主任研究員 (30308192)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エコール / 腸内フローラ / ダイゼイン / エストロゲン / マウス / β-エストロラジオール / エストロン / 脂質代謝 |
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| Research Abstract |
Equol is a metabolite of daidzein that is produced by the intestinal flora in the gut. Life style disease prevention of equol has been expected. In our research, In in vitro anaerobic incubation of equol-producing bacteria with estriol, estrone, andβ-estradiol, we firstly elucidated that equol-producing bacteria strongly converted estrone toβ-estradiol. Administration of equol-producing bacteria to mice fed the 0.05%-daidzein-10% lard diet affected the lipid metabolism and fecal bile acid concentration. The urinary amounts ofβ-estradiol were significantly lower in the mice administrated of equol-producing bacteria than in the mice administrated of physiological saline.
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