2011 Fiscal Year Final Research Report
Design and synthesis of novel anticancer compound based on the molecular mode of action of the marine pyrrole alkaloid lamellarin
| Project/Area Number |
21580248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ISHIBASHI Fumito 長崎大学, 大学院・水産・環境科学総合研究科, 教授 (10192486)
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| Co-Investigator(Kenkyū-buntansha) |
OSATOMI Kiyoshi 長崎大学, 大学院水産・環境科学総合研究科, 教授 (40253702)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 天然物化学 / 生理活性物質 |
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| Research Abstract |
Based on the molecular mode of action of topoisomerase I inhibition of the marine anticancer alkaloid lamellarin, two novel lamellarin analogs named as isolamellarin and bislactone were designed as anticancer agents and synthesized. Isolamellarin was shown to have twice as high antiproliferative activity as the parent compound lamellarin D on HeLa cell line due to topoisomerase I inhibition.
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