2011 Fiscal Year Final Research Report
Effects of placental transfer of phytoestrogen on physiological function in mammals
| Project/Area Number |
21580328
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Kyoto University |
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Principal Investigator |
KUME Shinichi 京都大学, 大学院・農学研究科, 教授 (90355454)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 植物エストロゲン / 新生仔マウス / 胎盤 / 哺乳動物 / 腸管免疫 / カルシウム代謝 / エストロゲン受容体 |
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| Research Abstract |
Coumestrol administration decreases the ALP activity in intestine of pregnant mice and increases the numbers of IgA-secreting cells in mammary gland of lactating mice. Coumestrol administration to maternal mice during pregnancy and lactation affects renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk. Phytoestrogens may act as both estrogen agonists and antagonists through estrogen receptor.
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