2011 Fiscal Year Final Research Report
Studies on Physiological Significance of Cytoskeleton Redistribution in the Mammalian Eggs and Its Signal Transduction Pathways
| Project/Area Number |
21580340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 哺乳動物 / 卵母細胞 / 卵成熟 / 細胞骨格 / シグナル伝達 |
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| Research Abstract |
Function of cytoskeleton in the mammalian oocytes during maturation was examined. Results revealed that microfilaments and microtubules may be differently involved in the mitochondrial redistribution according to the interphase and M-phase of the cell cycle. Dynamics of the motor proteins, myosin and kinesin, during oocyte maturation was also clarified. Furthermore, the distributional changes of intermediate filament proteins keratin, vimentin and nestin were shown. Effects of the specific inhibitors of the cell-cycle regulating factors cdc2 and MAP kinase kinase or Rho kinase inhibition on the cytoskeletal architecture were evaluated.
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[Journal Article] Ghrelin and leptin did not improve meiotic maturation of porcine oocytes cultured in vitro2010
Author(s)
Suzuki, H., Sasaki, Y., Shimizu, M., Matsuzaki, M., Hashizume, T. and Kuwayama, H.
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Journal Title
Reprod. Dom. Anim
Volume: Vol.45
Pages: 927-930
Peer Reviewed
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