2011 Fiscal Year Final Research Report
Investigation for physiological roles of glucocorticoid in the periovulatory follicle
| Project/Area Number |
21580357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 排卵 / 炎症 / 糖質コルチコイド / サイトカイン / 卵母細胞 |
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| Research Abstract |
Ovulation in mammal is an inflammatory reaction and the oocyte undergoes this process is likely to be influenced by various inflammatory factors. In this study we investigated the presence and action of enzymes that catalyze anti-inflammatory glucocorticoid (G) and inflammatory cytokine IL-1 in the bovine cumulus-oocyte complex (COC). Expression and action of enzymes that activate/inactivate G as well as IL-1 and its functional receptor are demonstrated in COC. These results suggest that G and IL-1 act together to regulate functions of periovulatory bovine COC.
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