2011 Fiscal Year Final Research Report
Control of the olfactory organ development by p53 family members
| Project/Area Number |
21580358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Kazuyuki 岩手大学, 農学部, 教授 (70148089)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生・分化 / 嗅覚器 / p53 |
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| Research Abstract |
To elucidate the role of p53 families in the development of olfactory organs, we cultured olfactory organs, repressed the p53 family gene expression in vitro, and investigated the effects on the cellular proliferation, death, gene expression, and morphology. Results in this study suggest that p53 family members coordinately regulate the expression of genes involved in the development of olfactory organs and induce the differentiation and proliferation of the olfactory cells and the vomeronasal receptor cells.
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