2011 Fiscal Year Final Research Report
Characterization and utilization of follistatin family proteins.
| Project/Area Number |
21580359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
ARAI Koji 東京農工大学, 農学部, 准教授 (70293016)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Toshio 東京農工大学, 農学部, 教授 (60372455)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 蛋白質 / 生理活性 |
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| Research Abstract |
To investigate pharmaceutical utilization of follistatin family proteins as TGF-beta superfamily antagonists, recombinant follistatin family proteins were expressed in E. coli. However, the proteins produced in E. coli did not show biological activities. Therefore, we examined mammalian cell-expression system. We could obtain biologically active proteins by the mammalian cell system but quantity and purity of the proteins remain to be improved.
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Research Products
(11 results)
