2011 Fiscal Year Final Research Report
Studies on endothelin for clinical use
| Project/Area Number |
21580369
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Rakuno Gakuen University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAIDA Kaname 独立行政法人産業技術総合研究所, バイオニクス研究センター, 研究員 (00357055)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 獣医学 / 伴侶動物 / 内科学 / 呼吸循環器 / 腫瘍 / エンドセリン |
|---|
| Research Abstract |
Endothelin-1(ET-1) is a bioactive peptide derived from vascular endothelial cells. Although ET-1 has recently received a lot of attention in human medicine because of its involvement in the pathophysiology of many diseases including heart failure, pulmonary hypertension, renal failure and tumors, no detailed studies on the clinical importance of ET-1 have been performed in veterinary medicine. In this study we investigated the feasibility of using ET-1 as a novel clinical marker to diagnose or assess the prognosis in canine cardiopulmonary and neoplastic disease. Dogs affected with cardiopulmonary disease, mitral valve regurgitation, tricuspid valve regurgitation and pulmonary hypertension, showed a significant increase in serum ET-1 levels compared to healthy dogs. In dogs presenting with hemangiosarcoma, a tumor that originates from vascular endothelial cells, significantly higher serum levels of ET-1 were observed than in dogs with non-neoplastic diseases or with neoplastic diseases other than hemangiosarcoma. Our observations suggest that serum ET-1 levels could be a novel clinical marker for these diseases.
|
-
-
-
-
-
-
[Journal Article] Evaluation of immunological status in tumor-bearing dogs2009
Author(s)
Itoh, H, Horiuchi, Y, Nagasaki, T, Sakonju, I, Kakuta, T, Fukushima, U, Uchide, T, Yamashita, M, Kuwabara, M, Yusa, S, Takase, K.
-
Journal Title
Vet. Immunol. Immunopathol
Volume: 123巻
Pages: 85-90
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Frog endothelins : cDNA cloning, sequence and evolutionary analysis of endothelins2009
Author(s)
Quan, J, Takizawa, S, Adur, J, Nara, E, Uchide, T, Saida, K.
Organizer
Eleventh International Conference on Endothelin
Place of Presentation
Montreal, Canada
Year and Date
2009-09-09
-
-
-
-
-
-
[Presentation] 長期生存を認めたイヌのT細胞性消化器型リンパ腫の一例2009
Author(s)
西田暁子, 中村篤史, 華園究, 金修敏, 濱田興, 堀知織, 薮崎尚弘, 平山和子, 谷山弘行, 内田英二, 打出毅
Organizer
日本獣医内科アカデミー2009年大会
Place of Presentation
東京
Year and Date
2009-02-15
-
