2011 Fiscal Year Final Research Report
Exploration of factors that have an influence on reassortment of influenza A virus
| Project/Area Number |
21580372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Hideo 東京大学, 医科学研究所, 助教 (50323639)
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| Project Period (FY) |
2009 – 2011
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| Keywords | インフルエンザ / 遺伝子再集合 / 断片化蛋白質 / コンプリメンテーション |
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| Research Abstract |
To explore causes that have an influence on reassortment of influenza A virus, virus like particles that carried HA and NA genome segments expressing split reporter proteins were generated. Reporter activity by protein complementation was detectable in cells transfected with protein expression plasmids. However the activity was reduced to 1/105 of the wild type activity. Due to the significant reduction of the activity the complementation could not be detected upon the VLP infection. The different amount of protein production between HA and NA segments may contribute the undetectable complementation upon VLP infection
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[Journal Article] F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding2012
Author(s)
Gorai T, Goto H, Noda T, Watanabe T, Kozuka-Hata H, Oyama M, Takano R, Neumann G, Watanabe S, Kawaoka Y
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Pages: 4615-20
DOI
Peer Reviewed
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