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2011 Fiscal Year Final Research Report

Molecular pathological study on the mechanism of epilepsy in familial epileptic dog

Research Project

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Project/Area Number 21580373
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionTottori University

Principal Investigator

MORITA Takehito  鳥取大学, 農学部, 准教授 (70273901)

Project Period (FY) 2009 – 2011
Keywordsイヌ / 遺伝 / グルタミン酸 / グルタミン酸トランスポーター / てんかん / 脳
Research Abstract

Prior study in this familial epileptic Shetland sheepdog has suggested that a decrease of GLT-1 expression in astrocytes in the cortex under the sulcus may be responsible for the occurrence of abnormal electroencephalographic waves. In this study, we investigated where the process of GLT-1 synthesis would be affected in astrocytes. Immunohistochemically, a decrease of GLT-1 immunolabellings was found in the cerebral cortex under the sulcus. In situ hybridization demonstrated no significant changes of GLT-1 mRNA labellings in the cortex under the sulcus of all familial dogs. In immunoelectron microscopy, GLT-1 immunolabellings were detected in endoplasmic reticulum(ER), while not the plasma membrane of astrocytes in the familial cortex under the sulcus. These results suggested at least two possibilities that GLT-1 synthesis process may stop in ER following an incomplete translation, or that the post-translational process of GLT-1 synthesis may be affected.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] てんかん家系シェルティー犬における神経細胞壊死の発生機序に関する病理学的研究2011

    • Author(s)
      櫻井優, ほか
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      20110919-21

URL: 

Published: 2013-07-31  

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