2011 Fiscal Year Final Research Report
Research on the pathophysiology of resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
| Project/Area Number |
21580394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
HARA Yasushi 日本獣医生命科学大学, 獣医学部, 教授 (00228628)
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| Co-Investigator(Renkei-kenkyūsha) |
TAGAWA Masahiro 日本獣医生命科学大学, 獣医学部, 教授 (90097072)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 犬下垂体ACTH産生腺腫 / クッシング病 / コルチゾール抵抗性 / ステロイド代謝酵素 |
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| Research Abstract |
Our study revealed that the expression of cortisol-metabolizing enzyme in the pituitary ACTH-secreting adenomas was higher than canine normal ACTH-secreting cells. Moreover, the expression of glucocorticoid receptor was seemed to be decreased in the pituitary ACTH-secreting adenomas. These changes may explain, in part, the resistance to glucocorticoid feedback in canine pituitary ACTH-secreting adenomas.
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Research Products
(5 results)
