2011 Fiscal Year Final Research Report
Development of nucleophilic cyanation to non-activated alkynes
| Project/Area Number |
21590003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
ARAI Shigeru 千葉大学, 大学院・薬学研究院, 准教授 (20285224)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アルキン / シアノ化 / パラジウム / 触媒 |
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| Research Abstract |
Nucleophilic cyanation has been developed by using catalytic amount of Pd(II) with non-activated alkynes and CN source. This fundamental and non-reported transformation in organometallic chemistry is named as cyanopalladation which promote electrophilic activation of alkynes and smooth nucleophilic attack from external CN source such as TMSCN. Furthermore, enynes and dienynes which have conjugated enyne units have been found for quite suitable substrates to install CN functionality in regio- and stereoselective fashion through cyclization protocol.
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