2011 Fiscal Year Final Research Report
Development of heterogeneous palladium on carbon-catalyzed aromatic amination
| Project/Area Number |
21590014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | (細目表キーワード)有機化学 |
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| Research Abstract |
Heterogeneous palladium on carbon(Pd/C)-catalyzed cross-coupling between amines and aromatic halides was developed.(Pd/C was quantitatively recovered and palladium species were hardly leached into the reaction media. Furthermore, intramolecular aromatic amination of 2-bromophenetylamine was found to proceed to afford the corresponding indoline. The reaction at higher temperature led to a quantitative aromatization of indoline to indole
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