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2011 Fiscal Year Final Research Report

SOLVENT-FREE AND COMPLETE SOLID-PHASE CATALYSIS USING SOLID CATALYST・SOLID SUBSTRATE・SOLID REAGENTS

Research Project

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Project/Area Number 21590015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionGifu Pharmaceutical University

Principal Investigator

SAJIKI Hironao  岐阜薬科大学, 薬学部, 教授 (50275096)

Co-Investigator(Kenkyū-buntansha) MONGUCHI Yasunari  岐阜薬科大学, 薬学部, 准教授 (40433205)
Project Period (FY) 2009 – 2011
Keywords固体触媒 / 固相触媒反応 / 接触還元 / 鈴木-宮浦反応 / パラジウム / プロセス化学 / 無溶媒 / 混合
Research Abstract

The solvent-free and solid-phase hydrogenation of various reducible functionalities was efficiently catalyzed by heterogeneous palladium on carbon(Pd/C) under ambient hydrogen pressure and temperature without any liquid materials. The Pd/C-catalyzed Suzuki? Miyaura coupling reaction between solid arylbromides and solid arylboronic acids in the presence of solid Pd/C and Cs2CO3 or K2CO3 leading to the formation of solid biaryls has also been efficiently achieved under the absolute solid-phase conditions.

  • Research Products

    (13 results)

All 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Carbon-Carbon Bond Formation by Ligand-free Cross-Coupling Reaction Using Palladium Catalyst Supported on Synthetic Adsorbent2012

    • Author(s)
      Yasunari Monguchi, Keita Sakai, Koichi Endo, Yuki Fujita, Masaru Niimura, Masatoshi Yoshimura, Tomoteru Mizusaki, Yoshinari Sawama, Hironao Sajiki
    • Journal Title

      Chem Cat Chem

      Volume: 4 Pages: 546-558

    • DOI

      DOI:10.1002/cctc.201100345

    • Peer Reviewed
  • [Journal Article] Solvent-Free Hydrogenation and Suzuki-Miyaura Coupling Using Pd/C2012

    • Author(s)
      Yasuhiro Uozumi, Toshihisa Suzuka
    • Journal Title

      Synfacts

      Volume: 8 Pages: 113

    • URL

      https://www.thieme-connect.com/ejournals/toc/synfacts/107922

  • [Journal Article] Palladium on carbon-catalyzed solvent-free and solid-phase hydrogenation and Suzuki-Miyaura reaction2011

    • Author(s)
      Yasunari Monguchi, Yuki Fujita, Shota Hashimoto, Mariko Ina, Tohru Takahashi, Ryo Ito, Kei Nozaki, Tomohiro Maegawa, Hironao Sajiki
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 8628-8634

    • DOI

      DOI:10.1016/j.tet.2011.09.043

    • Peer Reviewed
  • [Presentation] 担持型白金族触媒を利用した不均一系C-C及びC-N結合形成反応の開発2012

    • Author(s)
      佐治木弘尚
    • Organizer
      CPhI Japan国際医薬品原料・中間体展TLO/大学知的財産本部技術移転セミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-03-21
  • [Presentation] 合成吸着剤を担体とした機能性白金族触媒の開発研究2012

    • Author(s)
      佐治木弘尚
    • Organizer
      CPhI Japan国際医薬品原料・中間体展プロセス化学セミナー
    • Place of Presentation
      東京
    • Year and Date
      2012-03-21
  • [Presentation] 合成吸着剤を担体とした機能性白金族触媒の開発研究2011

    • Author(s)
      門口泰也
    • Organizer
      第6回プロセス化学ラウンジ
    • Place of Presentation
      熱海
    • Year and Date
      20111201-02
  • [Presentation] 均一系白金族触媒の機能多様性:既存の触媒に潜む新しい触媒活性の開拓と新規機能性触媒の開発2011

    • Author(s)
      佐治木弘尚
    • Organizer
      三重大学大学院工学研究科特別講演会
    • Place of Presentation
      津
    • Year and Date
      2011-12-16
  • [Presentation] 不均一系触媒の新機軸新しい有機合成手法と触媒の開発2010

    • Author(s)
      佐治木弘尚
    • Organizer
      日本薬学会北陸支部特別講演会
    • Place of Presentation
      金沢
    • Year and Date
      2010-05-25
  • [Presentation] 効率的金属触媒を用いた新しい有機合成反応手法の開発2010

    • Author(s)
      佐治木弘尚
    • Organizer
      CPHIJAPNA2010(第9回国際医薬品原料・中間体展)
    • Place of Presentation
      東京
    • Year and Date
      2010-04-21
  • [Presentation] 不均一系白金族触媒による新しい有機合成反応手法の開発2009

    • Author(s)
      佐治木弘尚
    • Organizer
      第3回ECOケミストリー研究会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-11-19
  • [Presentation] 不均一系触媒のモデルチェンジ-既存の不均一系触媒に新しい機能を吹き込みます-2009

    • Author(s)
      佐治木弘尚
    • Organizer
      セミナー"化学千一夜"「あすの化学への夢を語ろう」
    • Place of Presentation
      大津
    • Year and Date
      2009-06-13
  • [Presentation] 不均一系白金族触媒を利用した効率的有機合成反応の開発2009

    • Author(s)
      佐治木弘尚
    • Organizer
      大阪大学大学院薬学研究科講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-08
  • [Presentation] 不均一経白金族触媒の新機軸2009

    • Author(s)
      佐治木弘尚
    • Organizer
      CPhI JAPAN 2009(第8回国際医薬品原料・中間体展)
    • Place of Presentation
      東京
    • Year and Date
      2009-04-21

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Published: 2013-07-31  

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