2011 Fiscal Year Final Research Report
Synthesis of Highly-Functional DNA Binding Indole Alkaloids and Quinolones and Their Antitumor Activity
| Project/Area Number |
21590025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
KONAKAHARA Takeo 東京理科大学, 理工学部・工業化学科, 教授 (80084333)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Norio 東京理科大学, 理工学部, 准教授 (00328569)
IKEDA Norio 東京理科大学, 理工学部, 准教授 (00328569)
SAKAI Reiko 東京理科大学, 理工学部, 助教 (60516441)
NAKAIKE Yumi 東京理科大学, 理工学部, 助教 (10579775)
KIRAN Y. b. 東京理科大学, 理工学部, PD (50468708)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 抗腫瘍剤 / β-カルボリン / エリプチシン / ピリジン / ピリミジン / アポトーシス / ヘテロ環 / フルオラス |
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| Research Abstract |
We have succeeded to develop a series of new.-carboline derivatives, which shows practically-potent antitumor activity for HeLa S-3 cell line. This compound is a new type of an antitumor agent to induce apoptosis via interaction with.-tublin. In addition, we have succeeded to develop a new and effective synthetic method for the synthesis of ellipticine using Suzuki-Miyaura coupling reaction, and to develop new methods for construction of pyridine, pyrimidine, pyrrole, pyridone, and quinolone rings, which are expected as frameworks for a new type of antitumor agents.
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[Journal Article] 3-(3-Phenoxybenzyl) amino-υ-carboline : A novel antitumor drug targettingτ-tubulin2011
Author(s)
Reiko Ikeda, Masaki Kurosawa, Takazumi Okabayashi, Ayako Takee, Masamichi Yoshiwara, Tadashi Kumakura, Norio Sakai, Osamu Funatsu, Akinori Morita, Masahiko Ikekita, Yumi Nakaike, Takeo Konakahara
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 21
Pages: 4784-4787
Peer Reviewed
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