2011 Fiscal Year Final Research Report
Construction of CD-Sensitive Porphyrin Tweezer Systems and Their Application for the Direct Sensing of Chiral Organic Molecules
| Project/Area Number |
21590027
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Meiji Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | ビスポルフィリン / 円二色性 / 絶対配置 / ホスト分子 / 超分子 / 分散型CDスペクトル / CD励起子法 / 不斉認識 |
|---|
| Research Abstract |
Design, synthesis, and chirogenetic properties of novel pseudo-cofacial zinc porphyrin tweezers as an efficient circular dichroism(CD)-sensitive host molecule were explored. The notable features of the new tweezer systems are their facile synthetic accessibility and high binding affinity for a variety of optically active molecules, including diols, alcohols, and epoxides as well as amines, diamines, and aminoalcohols, providing an efficient direct, non-empirical determination of absolute configuration of these substrates at room temperature without the need for chemical derivatization.
|
-
-
-
-
-
[Journal Article] Highly Regioselective Rearrangement of 2, 3-Diaryloxiranes into 2, 2-Diarylacetaldehydes Catalyzed by Ytterbium Porphyrin Complex, Yb(TPP) OTf2009
Author(s)
T. Takanami, S. Nakajima, S. Nakadai, F. T. Takanami, S. Nakajima, S. Nakadai, F. Hino, K. Suda
-
Journal Title
Heterocycles
Volume: 77
Pages: 365-374
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
