2011 Fiscal Year Final Research Report
Synthetic Studies on Bioactive Polycyclic Ethers
| Project/Area Number |
21590029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
MORI Yuji 名城大学, 薬学部, 教授 (40121511)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ポリ環状エーテル / 全合成 / ガンビエロール / シガテラ毒 / 神経毒 / 海洋天然物 |
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| Research Abstract |
Ciguatera poisoning is a toxicological syndrome resulting from the ingestion of seafood contaminated by certain toxic polycyclic ethers produced by the epiphytic dinoflagellate Gambierdiscus toxicus. The toxin suite comprises ciguatoxins, maitotoxin, and gambierol. Gambierol consists of a ladder-shaped trans-fused octacyclic ring system with 18 stereogenic centers. The total synthesis of gambierol has been achieved utilizing an oxiranyl anion strategy in an iterative manner. The synthetic route includes direct carbon. carbon formation on epoxides, sulfonyl. assisted 6.endo cyclization, and ring expansion reaction of tetrahydropyranyl rings to oxepanes to forge the polycyclic skeleton of the target molecule.
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Research Products
(34 results)
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[Presentation] Total Synthesis of Gambierol2009
Author(s)
Yuki Hasegawa, Hiroki Furuta, Yuji Mori
Organizer
The 11^<th> International Kyoto Conference on New Aspect of Organic Chemistry(IKCOC-11)
Place of Presentation
京都
Year and Date
2009-11-11
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