2011 Fiscal Year Final Research Report
Intramolecula SN2' Cyclization Reaction by 1, 3-Chirality Transfer and Total Synthesis of Heterocyclic Natural Products
| Project/Area Number |
21590030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 1, 3-不斉転写 / 分子内SN2'型環化 / 天然化合物 / アルカロイド / マクロライド / 全合成 / Pd-catalyst / 選択的反応 |
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| Research Abstract |
New synthetic organic reaction has been developed and it has utilized for the synthesis of some natural products. Thus, optically active tetrrahydropyran, tetrahydrofuran, and piperidine rings have been prepared selectively by Pd(II)-catalyzed reaction. The reaction mechanism was proposed and proven on the basis of experimental evidence. For the synthesis of tetrahydroisoquinoline, Bi(OTf)_3 was found to be effective as a Lewis acid catalyst. Anti-cancer natural product(-)-apicularen A as well as natural alkaloid(-)-trolline and others have been synthesized.
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