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2011 Fiscal Year Final Research Report

Search for protective compounds from Egyptian traditional medicines on metabolic syndrome

Research Project

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Project/Area Number 21590031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

YOSHIKAWA Masayuki  京都薬科大学, 薬学部, 教授 (90116129)

Co-Investigator(Kenkyū-buntansha) MATSUDA Hisashi  京都薬科大学, 薬学部, 准教授 (40288593)
NAKAMURA Seikou  京都薬科大学, 薬学部, 助教 (20411035)
Project Period (FY) 2009 – 2011
Keywordsエジプト天然薬物 / メタボリックシンドローム / 伝承薬物 / 抗肥満作用 / 抗糖尿病作用 / PPARγアゴニスト様活性 / 3T3-L1細胞
Research Abstract

We focused Egyptian traditional medicine and have researched the active constituents for therapeutics of metabolic syndrome. As the results, the extract and the constituents from Egyptian moroheiya(the leaves of Corchorus olitorius) were found to show an anti-diabetic(PPARγagonist-like) effect. In addition, many constituents were isolated from Egyptian traditional medicines, Anastatica hierochuntica, Citrullus colocynthis, Bryonia cretica, and Cyperus longus.

  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] New terpenoids, olibanumols D. G, from traditional Egyptian medicine olibanum, the gum-resin of Boswellia carterii2011

    • Author(s)
      Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa
    • Journal Title

      J. Nat. Med

      Volume: 65 Pages: 129-134

    • DOI

      DOI:10.1007/s11418-010-0472-z

    • Peer Reviewed
  • [Journal Article] Four new ursane-type triterpenes, olibanumols K, L, M, and N, from traditional egyptian medicine olibanum, the gum-resin of Boswellia carterii2010

    • Author(s)
      Toshio Morikawa, Hideo Oominami, Hisashi Matsuda, Masayuki Yoshikawa
    • Journal Title

      Chem. Pharm. Bull

      Volume: 58 Pages: 1541-1544

    • DOI

      DOI:10.1248/cpb.58.1541

    • Peer Reviewed
  • [Journal Article] Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus2010

    • Author(s)
      Toshio Morikawa, Fengming Xu, Hisashi Matsuda, Masayuki Yoshikawa
    • Journal Title

      Chem. Pharm. Bull

      Volume: 58 Pages: 1379-1385

    • DOI

      DOI:10.1248/cpb.58.1379

    • Peer Reviewed
  • [Journal Article] Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an Egyptian natural medicine, Bryonia cretica : structures of new triterpene glycosides, bryoniaosides A and B2010

    • Author(s)
      Hisashi Matsuda, Souichi Nakashima, Osama Bashir Abdel-Halim, Toshio Morikawa, Masayuki Yoshikawa
    • Journal Title

      Chem. Pharm. Bull

      Volume: 58 Pages: 747-751

    • DOI

      DOI:10.1248/cpb.58.747

    • Peer Reviewed
  • [Journal Article] Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells2010

    • Author(s)
      Souichi Nakashima, Hisashi Matsuda, Yoshimi Oda, Seikou Nakamura, Fengming Xu, Masayuki Yoshikawa
    • Journal Title

      Bioorg. Med. Chem

      Volume: 18 Pages: 2337-2345

    • DOI

      DOI:10.1016/j.bmc.2010.01.046

    • Peer Reviewed
  • [Presentation] 薬食同源の視点から薬用食品の生体機能成分の探索-エジプトニガウリの細胞増殖抑制活性成分と標的分子の解明2011

    • Author(s)
      吉川雅之
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸学院大学(兵庫県)
    • Year and Date
      2011-10-22
  • [Presentation] 新規抗がん剤の開発を目指して-ククルビタン型トリテルペンの細胞増殖抑制活性と標的分子の解明-2011

    • Author(s)
      吉川雅之
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学(東京都)
    • Year and Date
      2011-09-24
  • [Presentation] アンザンジュ(Anastatica hierochuntica)のメラニン産生抑制活性成分2010

    • Author(s)
      吉川雅之
    • Organizer
      第27回和漢医薬学会大会
    • Place of Presentation
      京都薬科大学(京都府)
    • Year and Date
      2010-08-29
  • [Presentation] ファラオ天然薬物マリアハンド(Anastatica hierochuntica)のメラニン産生抑制活性成分2009

    • Author(s)
      吉川雅之
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2009-11-25
  • [Presentation] エジプト産モロヘイヤの脂肪細胞分化促進活性2009

    • Author(s)
      吉川雅之
    • Organizer
      第3回食品薬学シンポジウム
    • Place of Presentation
      近畿大学(大阪府)
    • Year and Date
      2009-11-13
  • [Presentation] ファラオ天然薬物マリアハンド(Anastatica hierochuntica)のメラニン産生抑制活性成分と作用様式2009

    • Author(s)
      吉川雅之
    • Organizer
      第3回食品薬学シンポジウム
    • Place of Presentation
      近畿大学(大阪府)
    • Year and Date
      2009-11-12

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Published: 2013-07-31  

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