2011 Fiscal Year Final Research Report
Development of antioxidant with lignan skeleton
| Project/Area Number |
21590032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIROKAWA Yoshimi 大阪大谷大学, 薬学部, 准教授 (40454582)
KITAMURA Maria 大阪大谷大学, 薬学部, 助教 (00434811)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 抗酸化剤 / リグナン / 有機化学 / 不斉合成 / [2, 3]-Wittig転位反応 |
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| Research Abstract |
We have investigated a syntheses of eupomatilones and tetrahydrofuran lignans to develop antioxidant with lignan skeleton. As a result, we have achieved a total synthesis of eupomatilones 1, 2, and 5 using asymmetric [2, 3]-Wittig rearrangement as a key reaction with high enantioselectivities(88.91% ee). We also succeeded to synthesize stereoisomers of THF-lignan.
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