2011 Fiscal Year Final Research Report
New evolution of continuous hetero-atomic chemistry
| Project/Area Number |
21590034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
MIYATA Okiko 神戸薬科大学, 薬学部, 教授 (90102110)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Masafumi 神戸薬科大学, 薬学部, 講師 (00340935)
MIYOSHI Tetsuya 神戸薬科大学, 薬学部, 助手 (10549992)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 合成化学 / オキシムエーテル / アルコキシアミン / 複素環化合物 / 極性転換反応 |
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| Research Abstract |
The oxime ether and the alkoxy amines where the nitrogen atom and the oxygen atom existed continuously were selected as the functional group bearing as consecutive hetero atoms. The continuous multistage reaction of these compounds with low environmental load was developed, and highly efficient and versatile synthetic methods of the heterocyclic compounds contained in a lot of medicines and the biologically active compounds were established. In addition, new polarity inversed reactions of the carbonyl compounds were developed by using these functional groups as an innovative method for carbon-carbon bond formation.
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