Synthesis of macrocyclic compounds that change their conformation depending on the external environment of stimulus

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tokushima Bunri University
• Principal Investigator: AZUMAYA Isao 徳島文理大学, 香川薬学部, 教授 (50276755)
• Project Period (FY): 2009 – 2011
• Keywords: McMurry coupling / ジアゾ化合物 / 分子認識 / 環境応答分子 / 環状分子

Research Abstract

In this project, large macrocyclic compounds that could change the size of the cavity depending on the external environment or stimulus were synthesized. The macrocyclic compound which contains the amide linkages changed its conformation by chemical introduction or removal of alkyl groups on the amide nitrogens. Furthermore, the macrocyclic compound which contains the azo linkages changed its conformation by irradiating of UV light or heating.

Research Products

• [Journal Article] Calix[3] amide-based Anion Receptors : High Affinity for Fluoride Ions and a Twisted Binding Model (2011)
  • Author(s): Katagiri, K.; Furuyama, T.; Masu, H.; Kato, T.; Matsumura, M.; Uchiyama, M.; Tanatani, A.; Tominaga, M.; Kagechika, H.; Yamaguchi, K.; Azumaya, I.
  • Journal Title: Supramolecular Chemistry Volume: 23巻 Pages: 125-130
  • DOI: DOI:10.1080/10610278.2010.514909
  • Peer Reviewed
• [Journal Article] Polymorphism or Pseudopolymorphism of a Macrocyclic Compound : Helical Structure, Layered Structure, and Pseudorotaxane Constructed by Weak Intermolecular Interactions (2010)
  • Author(s): Tohaya, T.; Katagiri, K.; Katoh, J.; Masu, H.; Tominaga, M.; Azumaya, I.
  • Journal Title: CrystEng Comm Volume: 12巻 Pages: 3493-3495
  • DOI: DOI:10.1039/c0ce00058b
  • Peer Reviewed
• [Presentation] Construction of Characteristic Crystal Structure using Polymorphism or Pseudopolymorphism (2011)
  • Author(s): 東屋功
  • Organizer: 第14回アジア化学会議
  • Place of Presentation: バンコク、タイ
  • Year and Date: 2011-09-06
• [Presentation] マクマリー反応による一段階環化生成物を経由する縮環系芳香族化合物の合成 (2011)
  • Author(s): 尾畑亮介、戸早太一、片桐幸輔、富永昌英、東屋功
  • Organizer: 第91回日本化学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-27
• [Presentation] 芳香族アミドの立体特性を利用した環状化合物の合成 (2011)
  • Author(s): 園川麻衣、池島規雄、片桐幸輔、富永昌英、東屋功
  • Organizer: 第91回日本化学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-27
• [Presentation] McMurry Couplingを利用した大環状化合物の合成と構造 (2010)
  • Author(s): 戸早太一、加藤潤也、片桐幸輔、桝飛雄真、富永昌英、東屋功
  • Organizer: 第90回日本化学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-28
• [Presentation] 特徴的なナノ構造を形成するブロック分子のデザインおよび合成 (2009)
  • Author(s): 東屋功
  • Organizer: 有機合成化学協会九州山口支部平成21年度第二回講演会
  • Place of Presentation: 長崎
  • Year and Date: 2009-11-20
• [Presentation] McMurry couplingを利用した大環状化合物の合成と結晶構造 (2009)
  • Author(s): 戸早太一、加藤潤也、片桐幸輔、桝飛雄真、富永昌英、東屋功
  • Organizer: 第20回基礎有機化学討論会
  • Place of Presentation: 群馬
  • Year and Date: 2009-09-28
• [Remarks]
  • URL: http://kp.bunri-u.ac.jp/poc/