2011 Fiscal Year Final Research Report
Formation of microdomains in cell membranes investigated by microscopic analyses of structures of membranes and proteins
| Project/Area Number |
21590037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
MIURA Takashi 東北大学, 大学院・薬学研究科, 准教授 (30222318)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 構造生物学 / 脂質膜 / 脂質ラフト |
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| Research Abstract |
The monomeric amyloid・peptide (A ・・ binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the liquid crystalline phase. Tightly packed phosphatidylcholine membranes appear to serve as a platform for non-electrostatic binding and self-association of A・. On the other hand, aggregated A・peptides bind to the phosphatidylcholine membrane both in the lamellar gel and the liquid crystalline phases. The binding of aggregated A・significantly reduces fluidity of the membrane in the liquid crystalline phase.
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