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2011 Fiscal Year Final Research Report

Formation of microdomains in cell membranes investigated by microscopic analyses of structures of membranes and proteins

Research Project

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Project/Area Number 21590037
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionTohoku University

Principal Investigator

MIURA Takashi  東北大学, 大学院・薬学研究科, 准教授 (30222318)

Project Period (FY) 2009 – 2011
Keywords構造生物学 / 脂質膜 / 脂質ラフト
Research Abstract

The monomeric amyloid・peptide (A ・・ binds to the phosphatidylcholine membrane in the lamellar gel phase but not in the liquid crystalline phase. Tightly packed phosphatidylcholine membranes appear to serve as a platform for non-electrostatic binding and self-association of A・. On the other hand, aggregated A・peptides bind to the phosphatidylcholine membrane both in the lamellar gel and the liquid crystalline phases. The binding of aggregated A・significantly reduces fluidity of the membrane in the liquid crystalline phase.

  • Research Products

    (14 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Conformational Regulation of Amyloid Beta-Peptide by Lipid Membranes and Metal Ions.2010

    • Author(s)
      Takashi Miura, Mayumi Yoda, Chihiro Tsutsumi, Kiyoko Murayama and Hideo Takeuchi
    • Journal Title

      Yakugaku Zasshi

      Volume: 130 Pages: 495-501

    • Peer Reviewed
  • [Journal Article] Regulation of secondary structure of peptides by lipid membranes.2010

    • Author(s)
      Takashi Miura
    • Journal Title

      Seibutsu Butsuri

      Volume: 50 Pages: 184-185

    • Peer Reviewed
  • [Journal Article] Role of His16 in the structural flexibility of the C-terminal region of human endothelin-12010

    • Author(s)
      Hirotsugu Hiramatsu, Hiroki Aduma, Yuriko Tanaka, Takashi Miura, and Hideo Takeuchi
    • Journal Title

      J. Mol. Struct

      Volume: 976 Pages: 328-332

    • Peer Reviewed
  • [Journal Article] Interactions between histidine and tryptophan residues in the BM2 proton channel from influenza B virus.2009

    • Author(s)
      K. Otomo, A. Toyama, T. Miura, H. Takeuchi
    • Journal Title

      J. Biochem

      Volume: 145 Pages: 543-54

    • Peer Reviewed
  • [Presentation] スフィンゴ脂質を含む脂質膜とアミロイドβペプチドとの相互作用2011

    • Author(s)
      東海林秀樹、三浦隆史、竹内英夫
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-30
  • [Presentation] HIV-1ウイルスのVprタンパク質におけるカチオン-π相互作用2011

    • Author(s)
      上山貴之、三浦隆史、竹内英夫
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-30
  • [Presentation] Ctr1による銅イオン細胞内取り込みの分子メカニズムMolecular mechanism of copper uptake by Ctr12011

    • Author(s)
      三浦隆史
    • Organizer
      化学系学協会東北大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-09-17
  • [Presentation] Structural Polymorphism and Copper Transport Function of the Extracellular N-Terminal Domain of Ctr12010

    • Author(s)
      Takashi Miura, Shiho Saito, Ako Okawara, Kenji Itoh, Shintaro Yamazaki and Hideo Takeuchi
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, U. S. A
    • Year and Date
      20101215-19
  • [Presentation] 脂質分子のパッキングがアミロイドβペプチドと脂質膜の相互作用に与える影響2010

    • Author(s)
      東海林秀樹、依田真由美、三浦隆史、竹内英夫
    • Organizer
      第48回生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      20100920-22
  • [Presentation] タンパク質中におけるカチオン-π相互作用の強さの評価2010

    • Author(s)
      上山貴之、三浦隆史、竹内英夫
    • Organizer
      第48回生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      20100920-22
  • [Presentation] エンドセリン1の構造安定性に対するHis16の役割2010

    • Author(s)
      平松弘嗣、我妻弘基、田中友里子、三浦隆史、竹内英夫
    • Organizer
      第37回生体分子科学討論会
    • Place of Presentation
      山口
    • Year and Date
      20100618-19
  • [Presentation] 脂質膜によるタウ微小管結合領域の構造転移と線維形成2009

    • Author(s)
      益山純英, 飛田英里, 三浦隆史, 竹内英夫
    • Organizer
      第36回生体分子科学討論会
    • Place of Presentation
      札幌
    • Year and Date
      20090619-20
  • [Presentation] 脂質膜により誘起されるタウ微小管結合領域の構造転移と線維形成2009

    • Author(s)
      益山純英, 飛田英里, 三浦隆史, 竹内英夫
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
  • [Remarks] 東北大学大学院薬学研究科、生物構造化学分野ホームページ

    • URL

      http://www.pharm.tohoku.ac.jp/~kouzou/kouzou.html

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Published: 2013-07-31  

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