2011 Fiscal Year Final Research Report
Structural evaluation of drug solution by ATR terahertz, NMR, DSC, and viscometry
| Project/Area Number |
21590038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
MORIBE Kunikazu 千葉大学, 大学院・薬学研究院, 准教授 (50266350)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Keiji 千葉大学, 大学院・薬学研究院, 教授 (50110341)
HIGASHI Kenjirou 千葉大学, 大学院・薬学研究院, 助教 (40451760)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 溶液構造 / 相互作用 / NMR / 原子間力顕微鏡 / テラヘルツ |
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| Research Abstract |
Physicochemical characterization of poorly water-soluble drug nanosuspension and the aqueous solution prepared by the cogrinding with pharmaceutical excipients was demonstrated. Dispersive state of drug nanoparticles as well as molecular state of drug and excipients in aqueous media was well demonstrated. Composition-dependent size changes were observed for drug nanoparticles prepared by cogrinding or solvent evaporation. Combined methods of suspended state NMR combined and liquid state NMR were useful to evaluate molecular states of stable drug nanosuspension. Drug supersaturated solution and drug solubilized solution were investigated by NMR measurements. We conclude that NMR techniques are the promising method to evaluate molecular interaction between drug and excipients as well as the mobility.
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