2011 Fiscal Year Final Research Report
Development of the prominent labeling reagents for LC/MS/MS and sensitive analysis of the biomolecules
| Project/Area Number |
21590039
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SANTA Tomofumi 東京大学, 大学院・薬学系研究科, 准教授 (30187306)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 分析化学 |
|---|
| Research Abstract |
Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) is widely used method. In this research, several labeling reagents were synthesized to enhance the sensitivity and selectivity in LC/MS/MS. These reagents enabled sensitive analysis of the biomolecules such as diseases markers. These methods were useful for the screening of the inherited metabolic disorders.
|
-
-
-
[Journal Article] Diagnosis of glutaric aciduria type 1 by measuring3-hydroxyglutaric acid in dried urine spots by liquid chromatography tandem mass spectrometry.2011
Author(s)
Al-Dirbashi OY, Kolker S, Ng D, Fisher L, Rupar T, Lepage N, Rashed MS, Santa T, Goodman SI, Geraghty MT, Zschocke J, Christensen E, Hoffmann GF, Chakraborty P.
-
Journal Title
Journal of Inherited Metabolic Disorders
Volume: 34
Pages: 173-180
DOI
Peer Reviewed
-
-
-
-
-
[Presentation] Analysis of3-hydroxyglutalic acid in dried urine spots by LC-MS/MS; application for the diagnosis of glutaric aciduria type 1.2011
Author(s)
Al-Dirbashi OY, Kolker S, Ng D, Fisher L, Rupar T, Lepage N, Rashed MS, Santa T, Goodman SI, Geraghty MT, Zschocke J, Christensen E, Hoffmann GE, Chakraborty P.
Organizer
SSIEM (Society for the Study of Inborn Error of Metabolism) annual symposium, Geneva,
Place of Presentation
Switzerland
Year and Date
20110830-0902
-
-
-
