2011 Fiscal Year Final Research Report
Biopharmaceutical delivery using transdermal patches having MN and EP systems
| Project/Area Number |
21590045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Josai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TODO Hiroaki 城西大学, 薬学部 (10383184)
ISHII Hiroshi 城西大学, 薬学部 (90383182)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マイクロニードル / エレクトロポレーション / 経皮パッチ / ドラッグデリバリーシステム |
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| Research Abstract |
Transdermal patch incorporating microneedle(MN) and electroporation(EP) improved skin permeation of high molecular weight of compound compared with MN or EP alone application. In addition to improvement of skin permeation for high molecular weight of compound, polystyrene particles having particle sizes of about 50 nm and 500 nm were delivered into the deeper part of skin with MN・EP systems. These results suggested that transdermal patch having MN・EP system would be a useful delivery system for biotherapeutics agents into skin.
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