2011 Fiscal Year Final Research Report
Study on the serum protein-mediated drug transport in biological membrane interface
| Project/Area Number |
21590054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膜インターフェイス / 血清アルブミン / 薬物輸送 |
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| Research Abstract |
This study was undertaken to evaluate serum protein-mediated drug transport. Through the investigation of the interaction between human serum albumin(HSA) and tissue cells, we explored the specific mechanism that HSA is incorporated and change its conformation so that the bound drug is released. In addition, our data suggests that HSA is incorporated into liver parenchymal cell via clathrin-medicated endocytosis.
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Research Products
(20 results)
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[Journal Article] Characterization of the hepatic cellular uptake of α1-acid glycoprotein(AGP), part 1 : a peptide moiety of human AGP is recognized by the hemoglobinβ-chain on mouse liver parenchymal cells2012
Author(s)
Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M
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Journal Title
J. Pharm. Sci
Volume: 101
Pages: 1599-1606
Peer Reviewed
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