2011 Fiscal Year Final Research Report
Research for the biosynthesis and degradation of lysophosphatidylinosiol, a novel endogenous cannabinoid liganad.
| Project/Area Number |
21590075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIURA Takayuki 帝京大学, 薬学部, 教授 (40130009)
OKA Saori 帝京大学, 薬学部, 講師 (80439562)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リゾリン脂質 / リゾホスファチジルイノシトール / ホスファチジルイノシトール / ホスホリパーゼA / カンナビノイド / マリファナ / GPR55 |
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| Research Abstract |
GPR55 is a seven-transmembrane G-protein-coupled receptor that has been proposed as a novel type of cannabinoid receptor. We identified lysophosphatidylinositol(LPI) as an agonist for GPR55, found that the intracellular phospholipase A1(DDHD DDHD1) is involved in the formation of 2-arachidonoyl-LPI.
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