2011 Fiscal Year Final Research Report
Physiological roles of a novel bioactive lipid lysophosphatidylinositol
| Project/Area Number |
21590076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質生化学 / カンナビノイド / Gタンパク質共役型受容体 / リゾリン脂質 |
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| Research Abstract |
GPR55 is a novel cannabinoid receptor. We found that its endogenous ligand is lysophosphatidylinositol(LPI). In this study, we obtained evidence that LPI plays some essential roles in the regulation of stress fiber formation. We next searched for the endogenous ligand for GPR35 which has 30% homology with GPR55.We found that 2-acyl lysophosphatidic acid(LPA) may act as an endogenous ligand for GPR35.
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