2011 Fiscal Year Final Research Report
Study on the roles of ezrin on epithelial physiology and cancer metastasis using ezrin knockdown mice.
| Project/Area Number |
21590082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
ASANO Shinji 立命館大学, 薬学部, 教授 (90167891)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAISHO Kenichi 滋賀医科大学, 医学部, 准教授 (50343223)
INDEN Masatoshi 立命館大学, 薬学部, 助教 (70512424)
HATANO Ryo 立命館大学, 薬学部, 助手 (60521713)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エズリン / 細胞骨格 / 遺伝子改変マウス / ガン転移 / トランスポーター / 上皮組織 / 神経ネットワーク |
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| Research Abstract |
Ezrin is an actin-binding protein which cross-links between plasma membrane proteins and cytoskeletons. It is essential for morphogenesis of the apical domain of epithelial cells as well as neuronal tissues. Recently, ezrin has been reported to be involved in membrane fusion, endocytosis/exocytosis, and targeting of specific transport proteins to the cell surface under the control of hormones and cellular signals. In this research project, we studied the roles of ezrin in the whole body in vivo using "ezrin-knock-down mice", and especially focused on its roles on epithelial architecture, transport, and tumor development. In conclusion, we found that ezrin is involved in epithelial architecture of GI tract, phosphate re-absorption in kidneys, and tumor development.
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[Journal Article] Sex hormones induce genderrelated difference in renal expression of a novel prostaglandin transporter, OAT-PG influencing basal PGE_2 concentration2012
Author(s)
Hatano, R., Onoe, K., Obara, M., Matsusbara, M., Kanai, Y., Muto, S. and Asano, S.
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Journal Title
Am. J. Physiol. Reanl Physiol
Volume: 302
Pages: 342-349
Peer Reviewed
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[Journal Article] A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules2010
Author(s)
Shiraya, K., Hirata, T., Hatano, R., Nagamori, S., Wiriyasermkul, P., Jutabha, P., Matsubara, M., Muto, S., Tanaka, H., Asano, S., Anzai, N., Endou, H., Yamada, A., Sakurai, H. and Kanai, Y.
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Journal Title
J. Biol. Chem
Volume: 285(29)
Pages: 22141-22151
Peer Reviewed
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[Journal Article] Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma2010
Author(s)
Ling, Z-Q. Mukaisho, K., Yamamoto, H., Chen, K. H., Asano, S., Araki, Y., Sugihara, H., Mao, W. M., Hattori, T.
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Journal Title
Cancer Sci
Volume: 101
Pages: 624-630
Peer Reviewed
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[Journal Article] FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues2009
Author(s)
Yamamoto, H., Okumura, K., Toshima, S., Mukaisho, K., Sugihara, H., Hattori, T., Kato, M. and Asano, S.
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Journal Title
Biol. Pharm. Bull
Volume: 32
Pages: 1148-1154
Peer Reviewed
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