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2011 Fiscal Year Final Research Report

Specific regulation for NFAT based on diversity of the NFAT family

Research Project

  • PDF
Project/Area Number 21590086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research Institution財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010)

Principal Investigator

KAMINUMA Osamu  財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (80342921)

Project Period (FY) 2009 – 2011
Keywords免疫学
Research Abstract

By employing NFATc2/NFATc4 chimera molecules, it was clarified that NFATc4 down-regulate cytokine expression in T cells via its CRD domain. The quantitative CN/NFAT binding assay revealed that there is a novel CN binding region in the CRD domain. It was found that WWTR1 regulates specific expression of NFATc4 in aortic smooth muscle cells by means of a comparative microarray analysis.

  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] Zinc finger protein, multitype 1 suppresses human Th2 development via down-regulation of IL-42011

    • Author(s)
      Kitamura N, Mori A, Tatsumi H, Nemoto S, Miyoshi H, Miyatake S, Kitamura F, Hiroi T, Kaminuma O
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Pages: S53-56

    • Peer Reviewed
  • [Journal Article] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo2011

    • Author(s)
      Abe A, Ohtomo T, Koyama S, Kitamura N, Kaminuma O, Mori A
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Pages: S110-116

    • Peer Reviewed
  • [Journal Article] CD44 is critical for airway accumulation of antigen-specific Th2 cells, but not Th1 cells, induced by antigen challenge in mice2011

    • Author(s)
      Kato S, Kaminuma O, Hiroi T, Mori A, Ohtomo T, Maeda S, Shimizu H, Obase Y, Oka M
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 3198-3207

    • Peer Reviewed
  • [Journal Article] Selective suppression of Th2 cytokines by C-terminal binding protein 2 in human T cells2010

    • Author(s)
      Kitamura F, Kitamura N, Mori A, Tatsumi H, Nemoto S, Miyoshi H, Miyatake S, Hiroi T, Kaminuma O
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Pages: S18-21

    • Peer Reviewed
  • [Journal Article] Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th-transfer model of Balb/c background2010

    • Author(s)
      Ohtomo T, Kaminuma O, Kitamura N, Suko M, Kobayashi N, Mori A
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Pages: S79-82

    • Peer Reviewed
  • [Journal Article] NFATサブタイプ阻害薬開発の意義と可能性2009

    • Author(s)
      神沼修
    • Journal Title

      薬学研究の進歩

      Volume: 25 Pages: 7-10

  • [Presentation] Antigen-specific Th2 cells specifically utilize CD44 to infiltrate into antigen-challenged lung in mice2011

    • Author(s)
      Kaminuma O, Kato S, Mori A, Hiroi T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-28
  • [Presentation] T細胞のIL-17産生に対するNFATファミリーの機能的相違2011

    • Author(s)
      神沼修、北村紀子、北村ふじ子、巽英樹、根本荘一、宮武昌一郎、森晶夫、廣井隆
    • Organizer
      アレルギー・好酸球研究会2011
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
  • [Presentation] Comparative analysis of steroid sensitivity of Th cells in vitro and in vivo2011

    • Author(s)
      Mori A, Abe A, Koyama S, Kitamura N, Yamaguchi M, Tanimoto H, Sekiya K, Oshikata C, Mitsui C, Taniguchi M, Ohtomo M, Maeda Y, Hasegawa M, Akiyama K, Ohtomo T, Kaminuma O
    • Organizer
      30th Congress of the European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2011-06-13
  • [Presentation] ZFPM1/CtBP1コンプレックスはGATA-3によるTh2分化を抑制する2010

    • Author(s)
      神沼修,北村紀子,森晶夫,巽英樹,根本荘一,廣井隆親
    • Organizer
      第60回日本アレルギー学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
  • [Presentation] T細胞クローン移入喘息モデルによるステロイド感受性解析2010

    • Author(s)
      安部暁美、大友隆之、神山智、北村紀子、神沼修、森晶夫
    • Organizer
      アレルギー・好酸球研究会2010
    • Place of Presentation
      東京
    • Year and Date
      2010-06-19

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Published: 2013-07-31  

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