2011 Fiscal Year Final Research Report
NR4A2-mediated regulation of IL-17-producing T cells for novel therapeutic strategy of autoimmune diseases
| Project/Area Number |
21590087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
OKI Shinji 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 第三研究室長 (50260328)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 自己免疫疾患 / 核内受容体 / Th17細胞 |
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| Research Abstract |
We identified the orphan nuclear receptor NR4A2 as a most significantly upregulated gene in peripheral T cells obtained from MS patients by microarray analysis. Further analysis employing experimental autoimmune encepharomyelitis(EAE) revealed that NR4A2 expression is selectively associated with IL-17-producing pathogenic T cells and preventive intervention for NR4A2 function ameliorates EAE symptom.
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