2011 Fiscal Year Final Research Report
Study on the bio-active molecule, DIF, found in the soil micro-organism Dictyostelium discoideum
| Project/Area Number |
21590090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
OSHIMA Yoshiteru 東北大学, 大学院・薬学研究科, 教授 (00111302)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞性粘菌 / 分化誘導因子 / がん / 糖尿病 / 免疫 / トリパノソーマ |
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| Research Abstract |
Dictyostelium differentiation-inducing factor DIF-1 and its derivatives (DIFs) are low-molecular weight compounds that possess anti-tumor and glucose-consumption-promoting activities. In this study, we performed comprehensive study on DIFs and have found the followings ; 1) DIF-1 inhibits mitochondrial malate dehydrogenase activity, 2) some DIF derivatives inhibit the invasion of a mouse osteosarcoma in vitro, 3) DIF-1 affects TCA cycle, 4) DIFs possess novel pharmacological activities, such as regulation of IL-2 production in T cells, induction of cardiomyocytes differentiation, and inhibition of Trypanosoma cell growth, and 5) DIFs can regulate Dictyostelium chemotaxis.
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[Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012
Author(s)
Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K
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Journal Title
Brit. J. Pharmacol
Volume: 165(4)
Pages: 870-879
Peer Reviewed
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[Presentation] Br-DIF-1による胚性癌腫細胞 (P19CL6) の1% DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012
Author(s)
瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
Organizer
日本薬学会第132年会
Place of Presentation
札幌
Year and Date
2012-03-29
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[Presentation] P19CL6胚性癌腫細胞の1% DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012
Author(s)
瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
Organizer
第85回日本薬理学会年会
Place of Presentation
京都
Year and Date
2012-03-16
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[Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells2011
Author(s)
Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
Organizer
The 28th Annual Meeting of ISHR Japanese Section
Place of Presentation
Tokyo
Year and Date
2011-12-03
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[Presentation] 新規生物資源の開拓ー昆虫寄生糸状菌と卵菌ー2010
Author(s)
菊地晴久, 佐藤雄一, 星朋子, 喜多山実, 関谷瑞樹, 礒辺真人, 三原健, 久保原禅, 佐藤大樹, 島津光明, 加藤泰弘, 倉田祥一朗, 大島吉輝
Organizer
第52回天然有機化合物討論会
Place of Presentation
静岡
Year and Date
2010-09-02
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