2011 Fiscal Year Final Research Report
Hyperreactivity of thermo-sensitive TRP channel-expressing sensory neurons under stress conditions, and effects of herbal medicines on hyperesthesia
| Project/Area Number |
21590100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Josai International University |
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Principal Investigator |
HORIE Syunji 城西国際大学, 薬学部, 教授 (50209285)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬効解析学 / 下部消化管 |
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| Research Abstract |
Psychological stress induces impairment of gastrointestinal tracts, leading to irritable bowel syndrome(IBS) accompanied by abdominal pain. The present study was designed with IBS model animals in order to elucidate the causes of IBS. As an important result, the stress induces the increased number of thermosensitive TRPV1-expressing nerve fibers, resulting in the hypersensitivity of visceral pain. Therefore, the inhibition of the abnormality of TRPV1 nerves in gut will make a contribution to the treatment of irritable bowel syndrome. I propose that Japanese Kampo medicine such as Daikenchuto will be a candidate that has the inhibitory effect of the abnormality on TRPV1 nerves in gut.
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[Journal Article] Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice2012
Author(s)
Matsumoto, K., Lo, Wah, M., Hosoya, T., Tashima, K., Takayama, H., Murayama, T., Horie, S
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Journal Title
Laboratory Investigation
Volume: 92(5)
Pages: 769-782
Peer Reviewed
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[Journal Article] Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system : relationship to peptidergic and nitrergic neurons2011
Author(s)
Matsumoto, K., Hosoya, T., Tashima, K., Namiki, T., Murayama, T., Horie, S
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Journal Title
Neuroscience
Volume: 172
Pages: 518-534
Peer Reviewed
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[Journal Article] Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum2011
Author(s)
Lo, Wah, M. W., Matsumoto, K., Iwai, M., Tashima, K., Kitajima, M., Horie, S., Takayama, H
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Journal Title
J. Nat. Med.
Volume: 65(1)
Pages: 157-165
Peer Reviewed
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[Journal Article] Neurogenic contraction of mouse rectum via the cyclooxygenase pathway : Change of PGE2-indueced contraction with dextran sulfate sodium-induced colitis2010
Author(s)
Hamada, Y., Murakami, I., Katoh, E., Yamane, S., Fujino, H., Matsumoto, K., Tashima, K., Horie, S., Murayama, T
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Journal Title
Pharmacological Research
Volume: 61(1)
Pages: 48-57
Peer Reviewed
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[Journal Article] Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats2009
Author(s)
Furuta, S., Shimizu, T., Narita, M., Matsumoto, K., Kuzumaki, N., Horie, S., Suzuki, T., Narita, M
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Journal Title
Neuroscience
Volume: 164(3)
Pages: 1252-1262
Peer Reviewed
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[Journal Article] Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine : high abundance and sensitivity in rectum and distal colon2009
Author(s)
Matsumoto, K., Kurosawa, E., Terui, H., Hosoya, T., Tashima, K., Murayama, T., Priestley, J. V., Horie, S
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Journal Title
Am. J. Physiol. Gastrointest. Liver Physiol
Volume: 297(2)
Pages: G348-360
Peer Reviewed
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[Presentation] Allyl Isothiocyanate, a Dietary Activator of TRPA1, Increases Gastric Mucosal Blood Flow Through TRPV1-Expressing and Non-Expressing Sensory Nerves in Rats2011
Author(s)
Kimihito Tashima, Masatoshi Yoshikubo, Masaki Raimura, Kenya Ozone, Hirokuni Okumi, Kenjiro Matsumoto, Atsushi Chino, Takao Namiki, Syunji Horie
Organizer
Digestive Disease Week 2011
Place of Presentation
Chicago, USA
Year and Date
20110507-11
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