2011 Fiscal Year Final Research Report
Prevention and treatment of neurodegenerative diseases(Alzheimer's disease and Parkinson's disease) via inhibition of Syk kinase.
| Project/Area Number |
21590106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
OHMURO Hiromi 武蔵野大学, 薬学研究所, 教授 (00124470)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Taizo 姫路獨協大学, 薬学部, 教授 (70346253)
HIMI Toshiyuki 武蔵野大学, 薬学研究所, 教授 (30222243)
YOSHIDA Lucia sachiko 武蔵野大学, 薬学研究所, 助教 (20240327)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経生物学 / アルツハイマー病 / パーキンソン病 / 抗炎症剤 |
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| Research Abstract |
The active substance of the herbal medicine 'Shikon', shikonin, shows strong anti-inflammatory properties due to its pharmacological effects like inhibition of Syk kinase activity. Because neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are suggested to occur on basis of chronic inflammation, we decided to investigate shikonin's preventive and therapeutic effects using animal models of the diseases. After 2 months oral administration of shikonin to mice presenting symptoms of these two diseases, improvement in cognitive symptoms was not clearly detected, but shikonin was suggested to ameliorate the symptoms of Parkinson's disease.
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[Journal Article] Shikonin directly inhibits nitric oxide synthases : possible targets that affect thoracic aorta relaxation response and nitric oxide release from RAW 264.7 macrophages2010
Author(s)
Yoshida, L. S, Kawada, T., Irie, K., Yuda, Y., Himi, T., Ikemoto, F., Takano-Ohmuro, H.
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Journal Title
J. Pharmacol. Sci.
Volume: 112(3)
Pages: 343-351
Peer Reviewed
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