2011 Fiscal Year Final Research Report
Basic research for novel neurotrophic drugs targeting glial endothelin receptors
| Project/Area Number |
21590108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
KOYAMA Yutaka 大阪大谷大学, 薬学部, 教授 (00215435)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 薬理学 |
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| Research Abstract |
On brain insults, such as stroke, subarachnoid hemorrhage and head trauma, brain edema occurs. Although brain edema is a mortal pathology, effective drug treatments for it have not been established. To generate a novel drug against brain edema, mechanisms underlying brain edema formation were examined bbyb using animal models. We found that endothelins, (ETs), a vasoconstricting peptides, are potent inducers of various edema factors in rat brain and in cultured glial cells. These findings suggest that inhibition of ET receptors in glial cells on brain insults have beneficial actions to prevent brain edema frormation.
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