2011 Fiscal Year Final Research Report
Research on the onset and progression of amyotrophic lateral sclerosis using genetically modified animals
| Project/Area Number |
21590110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Yasuhiro 摂南大学, 薬学部, 講師 (40330360)
YAMAMURO Akiko 摂南大学, 薬学部, 助手 (20340862)
ISHIMARU Yuki 摂南大学, 薬学部, 助教 (80611607)
KASAI Atsushi 摂南大学, 薬学部, 助教 (40454649)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 筋萎縮性側索硬化症 / アペリン / 活性酸素種 / 神経細胞死 |
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| Research Abstract |
We examined whether apelin is an endogenous neuroprotective factor using SOD1(G93A) mouse model of ALS. Double mutant apelin-deficient and SOD1(G93A) displayed the disease phenotypes earlier than SOD1(G93A) littermates. In addition, the number of motor neurons was decreased in the spinal cord of the double mutant mice. Furthermore, we showed that apelin enhanced the protective effect of VEGF on hydrogen peroxide-induced neuronal death in primary neurons. These results suggest that apelin/APJ system in the spinal cord has a neuroprotective effect against the pathogenesis of ALS, and that apelin may be a useful therapeutic target for ALS.
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