2011 Fiscal Year Final Research Report
Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction model
| Project/Area Number |
21590118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Hideshi 静岡県立大学, 薬学部, 講師 (70433208)
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| Project Period (FY) |
2009 – 2011
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| Keywords | テロメア / テロメラーゼ / 核酸 / 四重鎖 / ポルフィリン / 分子認識 / インシリコ創薬 |
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| Research Abstract |
Drug design, molecular docking, molecular dynamics simulation and synthesis of octacationic porphyrins bearing pyridiniums at their meso and terminal positions were carried out, because these were expected to interact with telomere quadruplex DNA more electrostatically and tightly than did tetracationic porphyrins. In addition, crystallization of the complex of telomere quadruplex DNA with the octacationic porphyrins was attempted.
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Research Products
(35 results)
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[Journal Article] ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes : Synthesis of 2-Silylanilines2011
Author(s)
Ikawa T., Nishiyama T., Shigeta T., Mohri S., Morita S., Takayanagi S., Terauchi Y., Morikawa Y., Takagi A., Ishikawa Y., Fujii S., Kita Y. Akai S.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 50
Pages: 5674-5677
Peer Reviewed
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[Journal Article] Binding of sulphatide to recombinant haemagglutinin of influenza A virus produced by a baculovirus protein expression system2010
Author(s)
Takahashi, T., Satoh, H., Takaguchi, M., Takafuji, S., Yokoyama, H., Fujii, S. & Suzuki, T.
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Journal Title
J. Biochem
Volume: 147
Pages: 459-462
Peer Reviewed
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[Journal Article] Unusual thermal disassembly of the SPFH domain oligomer from Pyrococcus horikoshii2009
Author(s)
Kuwahara, Y., Unzai, S., Nagata, T., Hiroaki, Y., Yokoyama, H., Matsui, I., Ikegami, T., Fujiyoshi, Y. & Hiroaki, H.
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Journal Title
Biophys. J.
Volume: 97
Pages: 2034-2043
Peer Reviewed
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