2011 Fiscal Year Final Research Report
Molecular basis for intracellular zinc-responsive system and its application as the imaging sensor for heavy metals.
| Project/Area Number |
21590136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOIZUMI Shinji (独)安衛研, 研究企画調整部, 特任研究員 (80183325)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOYAMA Tae 帝京大学, 薬学部, 助教 (30433882)
OSADA Yoichi 帝京大学, 薬学部, 助教 (50545572)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 環境衛生学 / 亜鉛センサー / 亜鉛 / 転写因子 |
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| Research Abstract |
MTF-1 is a heavy-metal dependent transcription factor and the molecular basis of its response to heavy metals is thought to be useful for developing a novel sensor system for heavy metals. Using various deletion and point mutatnts of MTF-1, we found that the Zn-finger domain does not solely function as the DNA-binding domain, but it plays multifunctional roles for the responses of MTF-1 against heavy metals. This indicates that the Zn-finger domain of MTF-1 is a useful module to design a novel artificial molecule for sensing heavy metals.
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