2011 Fiscal Year Final Research Report
The role of ketone body-utilization on obesity-induced metabolic syndrome
Project/Area Number |
21590137
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
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Research Institution | Hoshi University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Masahiro 星薬科大学, 薬学部, 准教授 (80328921)
|
Project Period (FY) |
2009 – 2011
|
Keywords | メタボリックシンドローム / ケトン体 / 脂肪細胞 |
Research Abstract |
In order to clarify the role of ketone body-utilization on metabolic disorders, we investigated obesity-induced alterations in the gene expression levels of the newly ketone body-utilizing enzyme, acetoacetyl-CoA synthetase(AACS), in peripheral tissues or central nerve system. As a result, we found that AACS gene expression was affected by treatment with free fatty acid and isoproterenol in white adipocytes. Moreover, we found the possibility that leptin up-regulates ketone body-utilization in neuro-cells and myocytes via activating the AACS transcription.
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