2011 Fiscal Year Final Research Report
Studies for the mechanism of the mucosal immunity of mice and the application for desensitization of environmental allergens
| Project/Area Number |
21590148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TESHIMA Reiko 国立医薬品食品衛生研究所, 代謝生化学部, 部長 (50132882)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Rhyosuke 国立医薬品食品衛生研究所, 代謝生化学学, 主任研究官 (50333357)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 粘膜免疫 / 免疫寛容 / 環境アレルゲン / 腸管上皮細胞 |
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| Research Abstract |
We newly obtained following four results in our studies :(1) Increase of IgA production from peyer's patch IgA+B220-cells by addition of culture medium of small-intestinal epithelial cell line MoS13 cells stimulated with TLR1/2 ligand,(2) Decrease of IgE production by yeast glucomannan(YGM)-Fag e 1 conjugates treated mice,(3) Decrease of IL21-production and Tfh cell differentiation by re-stimulated peyer's patch cells obtained from OVA-oral-sensitized BALB/c mice,(4) Identification of T-cell epitopes of major buckwheat allergen Fag e 2.
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