2011 Fiscal Year Final Research Report
Attenuatio of influenza virus by drug treatment and elucidation of mechanism of the attenuation
| Project/Area Number |
21590153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
HAYASHI Kyoko 富山大学, 大学院・医学薬学研究部(薬学), 講師 (60110623)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYA Yuji 富山大学, 大学院・医学薬学研究部(医学), 教授 (50255858)
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| Project Period (FY) |
2009 – 2011
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| Keywords | インフルエンザウイルス / 弱毒化 / グリセロール誘導体 / NS1タンパク質 |
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| Research Abstract |
The mechanism of attenuation of influenza A virus after treatment with a sphydrofuran derivative,(1R, 2R)-1-(5'-methylfur-3'-yl) propan-1, 2, 3-triol(MFPT) isolated from Streptomyces sp., was examined. The results were as follows : 1) MFPT-resistant viruses showed less pathogenicity in mice. 2) MFPTr virus clones showed lower growth in vitro. 3) Direct sequencing revealed a novel mutation in NS1 protein. 4) We tried and succeeded chemical synthesis of the compound.
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Research Products
(3 results)
