2011 Fiscal Year Final Research Report
Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patients
| Project/Area Number |
21590155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Takafumi 浜松医科大学, 医学部附属病院, 副薬剤部長 (80422749)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オピオイド鎮痛薬 / オキシコドン / がん性疼痛 / オーダーメイド医療 / 遺伝子多 / がん悪液質 / 緩和医療 |
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| Research Abstract |
Opioid analgesics possess the interindividual variations in pharmacokinetics and drug responses. Limited clinical data on the factors determining the interindividual variations are available in cancer pain patients. To date, the pain relief for cancer patients using opioid analgesics is uniformly performed according to the current Japanese package insert in clinical practices. This study evaluated the pharmacokinetics of and drug responses and tolerance to opioid analgesics based on genetic polymorphisms of drug-metabolizing enzymes, drug-transporter, and opioid receptor, and cachexia in cancer pain patients.
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