2011 Fiscal Year Final Research Report
Development of early diagnosis and therapeutic methods for peritoneal damage during peritoneal dialysis
| Project/Area Number |
21590165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUMOTO Shintaro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (70380988)
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| Research Collaborator |
MINE Toyoharu 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
NAKAJIMA Sayuri 長崎大学, 薬学部, 学部学生
HIRATA Haruna 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医療薬剤学 |
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| Research Abstract |
In this study, we developed an early diagnosis method for peritoneal damage during peritoneal dialysis. Using two marker substances having different molecular weight, we succeeded in evaluating both water-removing and substance-exchanging abilities of dialysis fluids simultaneously. Moreover, we successfully developed a gene transfer method to whole peritoneal organs using plasmid DNA and calcium carbonate particles. This method was simple, effective and safe in mice.
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[Journal Article] H, Fumoto S, Nishida K. Multiple components in serum contribute to hepatic transgene expression by lipoplex in mice2011
Author(s)
Yoshikawa N, Sakamoto K, Mizuno S, Sakaguchi J, Miyamoto H, Mine T, Sasaki H, Fumoto S, Nishida K.
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Journal Title
Journal of Gene Medicine
Volume: 13
Pages: 632-643
Peer Reviewed
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