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2011 Fiscal Year Final Research Report

Establishment of individualized dosage regimen based on pharmacodynamic model considering efficacy expression process of biological agents for rheumatoid arthritis

Research Project

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Project/Area Number 21590181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

YAMADA Yasuhiko  東京薬科大学, 薬学部, 教授 (40158225)

Project Period (FY) 2009 – 2011
Keywords医薬品情報・安全性学 / 投与設計 / 臨床 / 薬剤反応性 / 薬学 / 遺伝子
Research Abstract

Based on pharmacodynamic model for pharmacotherapy of rheumatoid arthritis, it was thought that the effect of infliximab appeared comparatively early, although its variation was large. In contrast, the effects of adalimumab and etanerscept appeared slowly, whereas these were stably. Regarding the individual variation, the level of TNFα by the influence of single nucleotide polymorphisms(SNPs) in TNFα gene was different. It was considered that dosage regimen of each drug for individual patient can be established with the developed model in view of the individual quantitative factor of TNFα.

  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Theory-based analysis of anti-inflammatory effect of infliximab on Crohn's disease and rheumatoid arthritis2012

    • Author(s)
      K. Kimura, R. Takayanagi, H. Yokoyama, Y. Yamada
    • Journal Title

      Rheumatology International

      Volume: 32 Pages: 145-150

    • Peer Reviewed

URL: 

Published: 2013-07-31  

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