2011 Fiscal Year Final Research Report
Analysis of mtabolome in relation to endocrinological and metabolic diseases by soft ionization mass spectrometry
| Project/Area Number |
21590184
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MITAMURA Kuniko 近畿大学, 薬学部, 准教授 (70242526)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 臨床化学 |
|---|
| Research Abstract |
Highly sensitive and specific soft ionization mass spectrometry for the determination of tetrahydrocorticosteroids, bile acids, and oxysterols, which are conjugated with glucuronic and sulfuric acids, glutathione, and N-acetylcysteine, have been developed. The developed methods were useful for diagnosis of endocrinological and metabolic diseases.
|
-
-
-
[Journal Article] Synthesis of 3-and 21-monosulfates of[2, 2, 3ss, 4, 4-^<2> H_5]-tetra-hydrocorticosteroids in the 5ss-series as internal standards for mass spectrometry2011
Author(s)
Ikegawa S, Nagae K, Mabuchi T, Okihara R, Hasegawa M, Minematsu T, Iida T, Mitamura K
-
Journal Title
Steroids
Volume: 76
Pages: 1232-1240
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Potential corticoid metabolites : chemical synthesis of 3-and 21-mono-and 3, 21-disulfate conjugates of tetrahydrocorticosteroids in the 5α-and 5ss-series2010
Author(s)
Okihara R, Mitamura K, Hasegawa M, Mori M, Muto A, Kakiyama G, Iida T, Shimada M, Mano N, Ikegawa S
-
Journal Title
Chem. Pharm. Bull
Volume: 58
Pages: 344-353
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
